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Interviews

What are the possible side effects of immune therapies for acute myeloid leukemia?

John F. DiPersio

April 7, 2022

During the ESH 3rd How to Diagnose and Treat Acute Leukaemias, Know AML spoke with John F. DiPersio, Washington University School of Medicine, St. Louis, US. We asked, What are the possible side effects of immune therapies for acute myeloid leukemia?

DiPersio begins by discussing the challenges of the targeted nature of immune therapies, including side effects like neurotoxicity. He goes on to discuss data concerning the lack of efficacy and clinical benefit, and explains the biology behind myeloid cell targeting. Finally, he outlines methods of overcoming these challenges, highlighting recently failed approaches such as proteomic methods.