AML is a rare aggressive cancer of the blood and bone marrow and is the most common form of acute leukemia in adults.
In healthy bone marrow, stem cells (immature cells) go on to form all of the blood cells we need to function normally. Blood stem cells can mature into more specified myeloid or lymphoid stem cells. A myeloid stem cell can then give rise to three different types of mature blood cell. These include
In patients with AML, one or more of these blood cell types do not develop as they should, which is due to certain changes in genetic material (DNA), known as genetic abnormalities. These abnormal cells are called leukemia cells and lack normal functionality. The leukemia cells then multiply, filling up the bone marrow and spilling into the blood, where they can spread to other parts of the body, such as the brain, skin, spleen, and gums. As a result, the production of normal blood cells is affected, and the bone marrow cannot make enough healthy blood cells.